The police officers are currently in Kaiserstrasse while they assess the situation. Cordons have been set up to protect the public, with members of the raid squad armed with heavy weapons. It is not yet known if anyone has been injured.
A police spokesman said the operation has been in place since 1pm local time.
The spokesman also confirmed that “shots were allegedly heard” by onlookers.
According to social media reports, the incident took place near the station distract.
One person wrote: “Avoid the station district in #Frankfurt! She @FRlokal reports gunshots there in the city center.”
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Additional reporting by Monika Pallenberg