The Premier League clash kicks off at 5.30pm at Old Trafford.
Cavani signed a one-year with United on deadline day, with the option for a further 12 months.
He has scored 341 goals in 556 club matches, including a record 200 in 301 appearances for PSG before his departure.
The Uruguayan will also wear the famous No 7 shirt for the Red Devils.
“Manchester United is one of the greatest clubs in the world, so it is a real honour to be here,” he said after completing his move.
“I’ve worked really hard during the time off and I feel eager to compete and represent this incredible club.